Cytotoxycity and antiplasmodial activity of phenolic derivatives from Albizia zygia (DC.) J.F. Macbr. (Mimosaceae)
Identifieur interne : 000173 ( Main/Exploration ); précédent : 000172; suivant : 000174Cytotoxycity and antiplasmodial activity of phenolic derivatives from Albizia zygia (DC.) J.F. Macbr. (Mimosaceae)
Auteurs : Romeol Romain Koagne [Cameroun, Espagne] ; Frederick Annang [Espagne] ; Bastien Cautain [Espagne] ; Jesús Martín [Espagne] ; Guiomar Pérez-Moreno [Espagne] ; Gabin Thierry M. Bitchagno [Cameroun] ; Dolores González-Pacanowska [Espagne] ; Francisca Vicente [Espagne] ; Ingrid Konga Simo [Cameroun] ; Fernando Reyes [Espagne] ; Pierre Tane [Cameroun]Source :
- BMC Complementary Medicine and Therapies [ 2662-7671 ] ; 2020.
Abstract
The proliferation and resistance of microorganisms area serious threat against humankind and the search for new therapeutics is needed. The present report describes the antiplasmodial and anticancer activities of samples isolated from the methanol extract of
The plant extract was prepared by maceration in methanol. Standard chromatographic, HPLC and spectroscopic methods were used to isolate and identify six compounds (
In general, compounds showed moderate activity against the human pancreatic carcinoma cell line MiaPaca-2 (10 < IC50 < 20 μM) and weak activity against other tumor cell lines such as lung (A-549), hepatocarcinoma (HepG2) and human breast adenocarcinoma (MCF-7and A2058) (IC50 > 20 μM). Additionally, the two semi-synthetic derivatives of quercetin 3-
The results of this study clearly suggest that, the appropriate introduction of acetyl groups into some flavonoids could lead to more useful derivatives for the development of an antiplasmodial agent.
Url:
DOI: 10.1186/s12906-019-2792-1
PubMed: 32020891
PubMed Central: 7076739
Affiliations:
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Le document en format XML
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<author><name sortKey="Gonzalez Pacanowska, Dolores" sort="Gonzalez Pacanowska, Dolores" uniqKey="Gonzalez Pacanowska D" first="Dolores" last="González-Pacanowska">Dolores González-Pacanowska</name>
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<series><title level="j">BMC Complementary Medicine and Therapies</title>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p id="Par1">The proliferation and resistance of microorganisms area serious threat against humankind and the search for new therapeutics is needed. The present report describes the antiplasmodial and anticancer activities of samples isolated from the methanol extract of <italic>Albizia zygia</italic>
(Mimosaseae).</p>
</sec>
<sec><title>Material</title>
<p id="Par2">The plant extract was prepared by maceration in methanol. Standard chromatographic, HPLC and spectroscopic methods were used to isolate and identify six compounds (<bold>1–6</bold>
). The acetylated derivatives (<bold>7–10</bold>
) were prepared by modifying 2-<italic>O</italic>
-<italic>β</italic>
-D-glucopyranosyl-4-hydroxyphenylacetic acid and quercetin 3-<italic>O</italic>
-<italic>α</italic>
-L-rhamnopyranoside, previously isolated from <italic>A. zygia</italic>
(Mimosaceae). A two-fold serial micro-dilution method was used to determine the IC<sub>50s</sub>
against five tumor cell lines and <italic>Plasmodium falciparum</italic>
.</p>
</sec>
<sec><title>Results</title>
<p id="Par3">In general, compounds showed moderate activity against the human pancreatic carcinoma cell line MiaPaca-2 (10 < IC<sub>50</sub>
< 20 μM) and weak activity against other tumor cell lines such as lung (A-549), hepatocarcinoma (HepG2) and human breast adenocarcinoma (MCF-7and A2058) (IC<sub>50</sub>
> 20 μM). Additionally, the two semi-synthetic derivatives of quercetin 3-<italic>O</italic>
-<italic>α</italic>
-L-rhamnopyranoside exhibited significant activity against <italic>P. falciparum</italic>
with IC<sub>50</sub>
of 7.47 ± 0.25 μM for compound <bold>9</bold>
and 6.77 ± 0.25 μM for compound <bold>10</bold>
, higher than that of their natural precursor (IC<sub>50</sub>
25.1 ± 0.25 μM).</p>
</sec>
<sec><title>Conclusion</title>
<p id="Par4">The results of this study clearly suggest that, the appropriate introduction of acetyl groups into some flavonoids could lead to more useful derivatives for the development of an antiplasmodial agent.</p>
</sec>
</div>
</front>
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</back>
</TEI>
<affiliations><list><country><li>Cameroun</li>
<li>Espagne</li>
</country>
<region><li>Andalousie</li>
</region>
</list>
<tree><country name="Cameroun"><noRegion><name sortKey="Koagne, Romeol Romain" sort="Koagne, Romeol Romain" uniqKey="Koagne R" first="Romeol Romain" last="Koagne">Romeol Romain Koagne</name>
</noRegion>
<name sortKey="Bitchagno, Gabin Thierry M" sort="Bitchagno, Gabin Thierry M" uniqKey="Bitchagno G" first="Gabin Thierry M." last="Bitchagno">Gabin Thierry M. Bitchagno</name>
<name sortKey="Simo, Ingrid Konga" sort="Simo, Ingrid Konga" uniqKey="Simo I" first="Ingrid Konga" last="Simo">Ingrid Konga Simo</name>
<name sortKey="Tane, Pierre" sort="Tane, Pierre" uniqKey="Tane P" first="Pierre" last="Tane">Pierre Tane</name>
</country>
<country name="Espagne"><region name="Andalousie"><name sortKey="Koagne, Romeol Romain" sort="Koagne, Romeol Romain" uniqKey="Koagne R" first="Romeol Romain" last="Koagne">Romeol Romain Koagne</name>
</region>
<name sortKey="Annang, Frederick" sort="Annang, Frederick" uniqKey="Annang F" first="Frederick" last="Annang">Frederick Annang</name>
<name sortKey="Cautain, Bastien" sort="Cautain, Bastien" uniqKey="Cautain B" first="Bastien" last="Cautain">Bastien Cautain</name>
<name sortKey="Gonzalez Pacanowska, Dolores" sort="Gonzalez Pacanowska, Dolores" uniqKey="Gonzalez Pacanowska D" first="Dolores" last="González-Pacanowska">Dolores González-Pacanowska</name>
<name sortKey="Martin, Jesus" sort="Martin, Jesus" uniqKey="Martin J" first="Jesús" last="Martín">Jesús Martín</name>
<name sortKey="Perez Moreno, Guiomar" sort="Perez Moreno, Guiomar" uniqKey="Perez Moreno G" first="Guiomar" last="Pérez-Moreno">Guiomar Pérez-Moreno</name>
<name sortKey="Reyes, Fernando" sort="Reyes, Fernando" uniqKey="Reyes F" first="Fernando" last="Reyes">Fernando Reyes</name>
<name sortKey="Vicente, Francisca" sort="Vicente, Francisca" uniqKey="Vicente F" first="Francisca" last="Vicente">Francisca Vicente</name>
</country>
</tree>
</affiliations>
</record>
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